Effect of product concentration
In case of a reversible reaction catalyzed by a enzyme, as per the law of mass action the rate of reaction is slowed down with equilibrium. So, rate of reaction is slowed, stopped or even reversed with increase in product concentration. This phenomena can be better explained by the equation.
In the above equation, in case of absence of the enzyme E3, the product C will accumulate. Enzymatic activity of E2 will be inhibited with accumulation of the product C. In such inborn error of one enzyme will block the whole pathway.
